Acacia nilotica Linn. (Fabeaece), commonly referred to as a ‘Babul or kikar’ is a well- known, medium- sized tree found broadly in tropical and subtropical regions. It has an inspiring array of medicinal properties and reported potential anti- oxidant behaviour. Acacia nilotica contributed a various compound, among which are alkaloids, volatile, essential oil, resins, oleosins, phenols and phenolic glycosides, flavonoids, steroids, terpenes and tannins. Acacia nilotica recognized to be rich in phenolic content, comprising condensed tannins and phlobatannins, along with gallic acid, protocatechuic acid, pyrocatechol, (+) catechin (-), epigallocatechin -7- gallate, and (-) epigallocatechin -5,7- digallate. Acacia nilotica is a remarked as a valuable plant for its medicinal activities, which leading to develop interests among the further new researchers. This review aimed to gather both early and recently published articles that validated the various different medicinal properties of Acacia nilotica trees. The researches finding from earlier studies indicated that Acacia extracts possess numerous therapeutic effects, such as Antipyretic, Anticancer, Antimicrobial, Antiparasitic, Anti-diabetics, Antihyperlipidemic, and Antimutagenic, Anti- inflammatory, Antinociceptive, Anti-diarrheal and Anti- Oxidant. This review compiles information concerning the phytochemistry, pharmacological properties and biological activities of the Acacia nilotica (Linn.)