Archives Issue

The advancement of drug delivery systems (DDS) has significantly enhanced therapeutic efficacy and patient compliance by enabling controlled and targeted delivery of pharmaceuticals. Polymers play a pivotal role in the development of modern DDS due to their versatile physicochemical properties, biocompatibility, and ability to modulate drug release profiles. This study investigates the application and performance of various natural and synthetic polymers—such as chitosan, alginate, polyethylene glycol (PEG), poly(lactic-co-glycolic acid) (PLGA), and polycaprolactone (PCL)—in drug delivery formulations. Each polymer offers unique characteristics; for instance, natural polymers like chitosan exhibit excellent biocompatibility and mucoadhesiveness, whereas synthetic polymers like PLGA offer tunable degradation rates and mechanical strength. The study evaluates polymer-based systems across multiple drug delivery platforms, including oral, transdermal, injectable, and nanoparticle-based methods. Factors such as polymer-drug interaction, drug release kinetics, stability, and bioavailability are discussed. Results demonstrate that the selection of an appropriate polymer is critical for optimizing drug release profiles and achieving therapeutic goals. Furthermore, polymer blends and surface modifications show promise in overcoming limitations of single polymer systems. Future research in smart polymers and stimuli-responsive DDS is likely to revolutionize the field, offering personalized and efficient drug delivery options. This comprehensive analysis underlines the importance of polymers in the evolution of next-generation drug delivery systems and provides insight into selecting suitable materials for specific pharmaceutical applications.

Originally from South Asia, the pomegranate (Punica granatum L.) is now produced in tropical and subtropical regions, including Mexico, which yields about 7,000 metric tons of the fruit annually. Because of its unique flavour and useful qualities, pomegranates are increasingly being used in various nations for the marketing of various goods including drinks, jams, and jellies, as well as for their ability to fight against illnesses and harmful microbes. The two widely grown pomegranate species that go by the names "Anar" and "Punica grantum" are Punica protopunica and Punica grantum. Numerous historical texts attest to its medicinal value. Because it contains significant phytochemical elements suchellagic acid, ellagitannins, punic acid, flavonoids, anthocyanins, estrogenic flavonoids, and flavones, it has a wide range of therapeutic applications. These ingredients have been used to cure a number of illnesses, including ulcers, snakebite, liver damage, diarrhea, helminthiasis, acidosis, bleeding, and respiratory issues. In addition, pomegranates have been shown to have remarkable enzymatic and cellular activity, particularly targeting enzymes such as COX, LOX, PLA2, and CA as well as cell cycle, division, and motility. Its clinical effectiveness has recently been documented in cases of obesity, male infertility, breast and prostate cancer, Alzhemier's illness, baby brain ischaemia, and arthritis. In light of the aforementioned therapeutic uses, pomegranates are poised to "explode" in the field of scientific research in the near future.

This research paper explores the representation of village life in Indian indigenous literature, examining how these works reflect the timeless tales of tradition, identity, and social change. Through a critical analysis of selected Indian indigenous literary works, this study reveals how these texts capture the essence of village life, exploring themes such as cultural heritage, identity, and social justice. The paper argues that Indian indigenous literature provides a unique window into the experiences of village life, offering insights into the complexities of tradition, modernity, and cultural identity. By examining the ways in which Indian indigenous literature reflects the timeless tales of village life, this study highlights the significance of these works in preserving and promoting India's rich cultural heritage. The research paper draws on a range of theoretical perspectives, including postcolonial theory, cultural studies, and literary theory. The analysis is based on a close reading of selected Indian indigenous literary works, including novels, short stories, and poetry. The findings of this study contribute to a deeper understanding of the representation of village life in Indian indigenous literature, highlighting the importance of these works in reflecting the timeless tales of tradition, identity, and social change. The study also underscores the significance of preserving and promoting Indian indigenous literature and culture, recognizing the valuable insights these works offer into the complexities of village life and cultural identity.

In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low water solubility, that negatively affect the drug circulation time and bioavailability. The stability studies, performed in mild conditions during their development or under stressing exposure to high temperature, hydrolytic medium or light source, have demonstrated the sensitivity of anticancer drugs to many parameter. For this reason, the formation of degradation products is assessed both in pharmaceutical formulations and in the environment as hospital waste. To date, numerous formulations have been developed for achieving tissue-specific drug targeting and reducing toxic side effects, as well as for improving drug stability. The development of prodrugs represents a promising strategy in targeted cancer therapy for improving the selectivity, efficacy and stability of active compounds. Recent studies show that the incorporation of anticancer drugs into vesicular systems, such as polymeric micelles or cyclodextrins, or the use of nanocarriers containing chemotherapeutics that conjugate to monoclonal antibodies can improve solubility, pharmacokinetics, cellular absorption and stability. In this study, we summarize the latest advances in knowledge regarding the development of effective highly stable anticancer drugs formulated as stable prodrugs or entrapped in nanosystems.